Drugs responsible of DRESS syndrome regulate IL-10 and TNF-α secretion
نویسندگان
چکیده
Background Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe drug-induced reaction that involves both the skin and the viscera. Several herpesvirus family members like EBV or HHV-6 can be detected coincidently with various clinical symptoms in DRESS. In addition, we have previously identified activated EBV specific cytotoxic CD8+ T cells as major actors in the pathophysiology of DRESS. In vitro, we have showed that DRESS inducer drugs increase production of EBV virus only on B-LCL lines from DRESS patients. However, drug effect on cytokines secretion has not been studied. Gene expression profiling of DRESS patients’ PBMC revealed that IL-10 and TNF-a were two of the most upregulated mRNA. We thus measured IL-10 and TNF-a secretion levels in DRESS patients’ serum and B-LCL lines following incubation with drugs.
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